Self-assembled RNA interference microsponges for efficient siRNA delivery
نویسندگان
چکیده
منابع مشابه
Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference.
RNA interference requires efficient delivery of small double-stranded RNA molecules into the target cells and their subsequent incorporation into RNA-induced silencing complexes. Although current cationic lipids commonly used for DNA transfection have also been used for siRNA transfection, a clear need still exists for better siRNA delivery to improve the gene silencing efficiency. We synthesiz...
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ژورنال
عنوان ژورنال: Nature Materials
سال: 2012
ISSN: 1476-1122,1476-4660
DOI: 10.1038/nmat3253